Cefixime Side Effects: What You Need to Know Before Taking It

When you’re prescribed cefixime, a third-generation oral antibiotic used to treat bacterial infections like ear infections, bronchitis, and urinary tract infections. Also known as Suprax, it’s often chosen because it’s taken once a day and works against a broad range of bacteria. But like all antibiotics, it doesn’t come without risks. You might feel fine after starting it, but some side effects show up days later — or worse, they sneak up when you least expect them.

Most people tolerate cefixime well, but about 1 in 10 report digestive issues like diarrhea, nausea, or stomach cramps. These aren’t just "upset stomach" complaints — they can be signs of something more serious, like Clostridioides difficile infection, a dangerous gut infection triggered by antibiotics killing off good bacteria. If you get watery or bloody diarrhea after starting cefixime, stop taking it and call your doctor. Don’t wait. This isn’t normal. Other less common but serious reactions include allergic rashes, swelling of the face or throat, and unusual tiredness. If you’ve had a penicillin allergy before, you’re at higher risk — cefixime is in the same drug family. Your body doesn’t care about brand names; it reacts to the chemical structure.

Some people wonder if cefixime affects birth control. While no strong evidence says it does, antibiotics can sometimes mess with how your body processes hormones. If you’re on the pill, use backup protection just to be safe. Also, cefixime can interact with blood thinners like warfarin, making your blood clot slower. If you’re on any other meds — even over-the-counter ones — tell your pharmacist. They’ve seen it all. And if you’re pregnant or breastfeeding, cefixime is generally considered low risk, but always check with your provider. It’s not the antibiotic for every infection, and using it when you don’t need it only makes future infections harder to treat.

Below, you’ll find real, detailed reviews and comparisons from people who’ve taken cefixime — and others who’ve tried alternatives like amoxicillin, azithromycin, or ciprofloxacin. We cover what worked, what didn’t, and what symptoms people missed until it was too late. No fluff. No marketing. Just what you need to know before you swallow that first pill.